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March 18, 2011

27 Things You Should Know About Seizure Medications

Studies show about 20-30% of autistics have epilepsy. If you are a parent, teacher, caregiver, relative, friend or advocate of someone with autism and epilepsy, you need to read this:

1. Lamictal (lomotrigine) can INCREASE myoclonic seizures (especially NOCTURNAL myoclonus)

2. Taking Tylenol may lower Lamictal levels

3. Lamictal is good for Frontal Lobe Epilepsy

4. Keppra (levetiracetam) can DECREASE myoclonic seizures

5. Taking B-Vitamins can mitigate Keppra's infamous adverse behavioral side effects

6. Keppra is good for hippocampal related seizures

7. Depakote linked to hyperammonemia (dangerous levels of ammonia in your body)

8. Klonopin (clonazepam) is a benzodiazepine to help treat ATONIC (drop) seizures

9. Best drugs for atonic seizures: Depakote, Lamictal, Topamax (topiramate)

10. Best Drugs for myoclonic seizures: Keppra, Klonipin, Topamax

11. Worst Drugs for myoclonic seizures: Tegretol (carbamazepine), Dilantin (phenytoin), Phenobarbital, Sabril (vigabatrin)

12. Topamax is  best for temporal lobe epilepsy

13. Klonipin sometimes helpful for REM sleep disorder related epilepsy

14. Klonipin and Lamictal can increase tonic-clonic seizure activity in some people

15. Generic seizure medications can KILL YOU. They are NOT the same as drug first approved by FDA for same treatment. Generic formulations can change frequently. God only knows what you're
It is absolute BULL%$# that a generic medication is always the same as the brand .... Probably not. The same wasn't true for other classes of medications.

Source: Brand Name and Generic Drugs NOT equivalent

16. 5-Ht1A  receptors appear low in people with epilepsy

17.  Tonic Clonic seizures aren’t only seizure that  go “status”. Ex: Absence and myoclonus status epilepticus

18. Taking seizure medication increases risk of CHOLINE deficiency

19. Choline deficiency places undue stress on liver

20. Choline has anti-inflammatory properties. Lack of choline=higher inflammation markers= elevated levels of homocysteine

21. Seizure medications deplete your body of Folic Acid, Vitamin D and Carnitine.

22. Coginitive decline caused by seizure drugs like Topamax and Depakote can be thwarted by natural herbs like Bacopa Monnieri

23. NREM parasomnia may co-exist with epilepsy in same patient

24. Studies show Ginkgo Biloba, another nootropic with antioxidant properties, reduced seizure activity in rats. Go Ben. Other studies show it increased seizures in humans. Go figure.

25. Piracetam is a nootropic drug commonly prescribed in other countries, and used to treat autism and epilepsy. Studies show piracetam modulates acetylchoine levels, increases cognition and has few side effects. Too bad it’s not approved for epilepsy in USA. And FDA wants it to stay that way.

26. Medical Marijuana is said to help people with epilepsy. At first, I thought this was utter bull and just another ploy to get non-pot heads to accept medical cannibis. However, upon careful analysis, it appears that people with epilepsy and depression, are low in 5 HT 1a receptors. Pot high in "Cannabidiol" appears to act as a 5 HT1 a, receptor agonist (increases action) an action that is involved in it anxiolytic and neuroprotective effects.

27.Recent studies have indicated that nicotine can be used to help adults suffering from autosomal dominant nocturnal frontal lobe epilepsy. The same areas that cause seizures in that form of epilepsy are responsible for processing nicotine in the brain.Source: ^ "Nicotine as an antiepileptic agent in ADNFLE: An n-of-one study".

Finding effective treatments for individuals with autism, seizures and/or self-injurious behavior, is a puzzle, an enigma, a brain teaser, a complex problem--one that tests the resolve and skills of all involved to recognize patterns, ask questions, make discoveries and use deductive reasoning--- to put together pieces in a logical manner and achieve desired outcome: Controlling Seizures. And maximizing  full potential of the autistic individual.

Please site blog link/source and author if you reprint this material.


Anonymous said...

I am almost afraid I've developed a tendency to sleep-blog... the parallels are so close it's spooky. One question: been fighting the generic battle for some time (mainly because some are apparantly coming in from off-shore production facilities) - can you give any citation for #15?

KC's Warrior Mama said...

Would you mind if I post this on my blog, citing your blog as the source?

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